JEMI-PEARLS

Crossing Barriers: How JC Virus Crosses the Blood Brain Barrier and Induces Progressive Multifocal Leukoencephalopathy in Patients on Disease-Modifying Therapies.

Wednesday, September 5, 2018

Maria-Elizabeth Baeva​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease caused by the John Cunningham virus (JCV).

Leishmania RNA Virus: Mere Endosymbiont or Major Player in Leishmania-Associated Disease?

Wednesday, September 5, 2018

Shivani Mysuria​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Leishmaniasis is a vector-borne disease caused by various species of Leishmania parasites. They are transmitted by the bites of infected sand flies and go on to infect host macrophages.

Bioengineering ZIKV-like Exosomes in the Treatment of Drug- Resistant Glioblastoma

Wednesday, September 5, 2018

Rory K.M. Long​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Oncolytic viruses are becoming one of the most promising avenues of therapy against a diverse range of cancers due to inherent tumour specificity. Classically, the difficulty associated with the use of viruses for cancer treatment has been how to minimize off target effects.

Salivary Exosomal microRNAs: Discovery and Potential Biomarkers for Human Papillomavirus-Associated Oral Squamous Cell Carcinoma

Wednesday, September 5, 2018

Syed Shuja Raza​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Exosomes are small, membrane bound vesicles secreted by many types of cancers including oral squamous cell carcinoma (OSCC), and have been found to contain various cargo, including microRNAs (miRNAs).

The War on Arboviruses: Leveraging Co-Infection Inhibition and Endogenous Viral Elements Towards Inhibiting Arbovirus Horizontal Transmission

Wednesday, September 5, 2018

Brayden Wilkinson​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Clinically significant arboviruses like dengue virus, zika virus, and chikungunya virus currently impose a major global health crisis due to their high frequency of transmission and from the lack of approved antivirals and vaccines against them.

Ebola Virus and Malaria Coinfection: How Infection with One Pathogen May Protect Against Another

Wednesday, September 5, 2018

Naomi Fettig​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Both malaria and Ebola virus have been the centre of global health care efforts in recent years, due to the massive ongoing disease burden of malaria and the largest Ebola outbreak in history in West Africa.

MERS-CoV: Identifying Viral and Host Factors Associated with Transmission, Pathogenesis, and Treatment Development

Wednesday, September 5, 2018

Habibur Rahman​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel betacoronavirus that is associated with a high mortality rate (~36%) and is endemic in the Middle East. Since 2012, there have been 2100 laboratory confirmed cases and 730 deaths associated with MERS-CoV in 27 countries.

A Cure for Cancer? The Therapeutic Potential of Combining Oncolytic Viruses and Chimeric Antigenic Receptor T-Cell Therapy

Wednesday, September 5, 2018

Andrew P. Golin​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Cancer continues to be a devastating diagnosis. Fortunately, active research has developed and refined two cancer therapies: oncolytic virotherapy and the novel chimeric antigen receptor (CAR) T-cell therapy.

Human Endogenous Retroviruses as Contributors of Exosomemediated Autoimmunity in Systemic Lupus Erythematosus

Wednesday, September 5, 2018

Haya AbuZuluf

Volume 3
Fall 2017 / Winter 2018

SUMMARY At least 8% of the human genome was formed by integration of retroviral DNA sequences. These sequences are remnants of ancient infections that have accumulated mutations over millions of years.

Targeting the Gut Microbiome in HIV/AIDS: New Therapeutic Opportunities

Wednesday, September 5, 2018

Zoe O’Neill​

Volume 3
Fall 2017 / Winter 2018

SUMMARY Despite major advances in HIV antiretroviral therapy (ART), complete elimination of the disease has not been achieved. Recently, the importance of the gutassociated lymphoid tissues (GALT) and the resident microbiota in HIV pathogenesis has been highlighted.

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